5HG2

Backbone Modifications in the Protein GB1 Helix: beta-3-Ala24, beta-3-Lys28, beta-3-Lys31, beta-2-Asn35

5HG2 の概要

• エントリーDOI: 10.2210/pdb5hg2/pdb
• 関連するPDBエントリー: 5HFY 5HI1
• 分子名称: Immunoglobulin G-binding protein G, GLYCEROL, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: synthetic protein, de novo protein
• 由来する生物種: Streptococcus sp. group G
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 25343.78

構造登録者

Tavenor, N.A.,Reinert, Z.E.,Lengyel, G.A.,Griffith, B.D.,Horne, W.S. (登録日: 2016-01-07, 公開日: 2016-02-24, 最終更新日: 2023-11-15)

主引用文献

Tavenor, N.A.,Reinert, Z.E.,Lengyel, G.A.,Griffith, B.D.,Horne, W.S.
Comparison of design strategies for alpha-helix backbone modification in a protein tertiary fold.
Chem.Commun.(Camb.), 52:3789-3792, 2016

PubMed Abstract: We report here the comparison of five classes of unnatural amino acid building blocks for their ability to be accommodated into an α-helix in a protein tertiary fold context. High-resolution structural characterization and analysis of folding thermodynamics yield new insights into the relationship between backbone composition and folding energetics in α-helix mimetics and suggest refined design rules for engineering the backbones of natural sequences.

PubMed: 26853882
DOI: 10.1039/c6cc00273k

実験手法

X-RAY DIFFRACTION (1.8 Å)