5HCV

Identification of Spirooxindole and Dibenzoxazepine Motifs as Potent Mineralocorticoid Receptor Antagonists

5HCV の概要

• エントリーDOI: 10.2210/pdb5hcv/pdb
• 分子名称: Mineralocorticoid receptor, 6-[(~{E})-(3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene)methyl]-4~{H}-1,4-benzoxazin-3-one, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: mineralocorticoid receptor, ligand-binding domain, mr-lbd, antagonists, co-crystal, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P08235
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 90776.36

構造登録者

Chen, G.,McKeever, B.M. (登録日: 2016-01-04, 公開日: 2016-03-09, 最終更新日: 2023-09-27)

• 主引用文献: Lotesta, S.D.,Marcus, A.P.,Zheng, Y.,Leftheris, K.,Noto, P.B.,Meng, S.,Kandpal, G.,Chen, G.,Zhou, J.,McKeever, B.,Bukhtiyarov, Y.,Zhao, Y.,Lala, D.S.,Singh, S.B.,McGeehan, G.M.; Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.; Bioorg.Med.Chem., 24:1384-1391, 2016; PubMed: 26897089; DOI: 10.1016/j.bmc.2016.02.014

実験手法

X-RAY DIFFRACTION (2.5 Å)