5HCL

Crystal Structure of the first bromodomain of BRD4 in complex with DMA

Summary for 5HCL

Entry DOI	10.2210/pdb5hcl/pdb
Descriptor	Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15248.57
Authors	Dong, J.,Weber, F.E.,Caflisch, A. (deposition date: 2016-01-04, release date: 2017-01-25, Last modification date: 2024-01-10)
Primary citation	Ghayor, C.,Gjoksi, B.,Dong, J.,Siegenthaler, B.,Caflisch, A.,Weber, F.E. N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment. Sci Rep, 7:42108-42108, 2017 Cited by PubMed: 28176838 DOI: 10.1038/srep42108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation