5HBA

Globular Domain of Zebrafish Complement 1qA protein

5HBA の概要

• エントリーDOI: 10.2210/pdb5hba/pdb
• 分子名称: Uncharacterized protein, SULFATE ION (3 entities in total)
• 機能のキーワード: immune system, complement 1q
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44669.67

構造登録者

Xia, C.,Yuan, H.,Chen, R. (登録日: 2015-12-31, 公開日: 2016-07-27, 最終更新日: 2024-10-16)

主引用文献

Yuan, H.,Chen, R.,Tariq, M.,Liu, Y.,Sun, Y.,Xia, C.
Crystal structure of zebrafish complement 1qA globular domain.
Protein Sci., 25:1883-1889, 2016

PubMed Abstract: C1q contains three globular domains (C1qgD) that are the key functional component of the classical complement system. C1qgD can interact with important immune molecules, including IgG and C-reactive protein (CRP) to form defense systems to protect animals. Here, the first non-mammalian structure, zebrafish C1qA globular domain (Dare-C1qAgD) was solved. Although the overall architecture of Dare-C1qAgD is similar to human C1qA, residues involved in C1qBgD, C1qCgD, and CRP binding are somewhat different while residues involved in IgG binding are not present in zebrafish. The structure gives insight into how human and fish C1qA evolved from an ancestral protein.

PubMed: 27391278
DOI: 10.1002/pro.2980

実験手法

X-RAY DIFFRACTION (2.05 Å)