5HA9

Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer

5HA9 の概要

• エントリーDOI: 10.2210/pdb5ha9/pdb
• 分子名称: Poly [ADP-ribose] polymerase 1, GLYCEROL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79694.08

構造登録者

Fu, L.,Peng, H.,Zhang, L.,Ouyang, L. (登録日: 2015-12-30, 公開日: 2016-03-09, 最終更新日: 2024-03-20)

• 主引用文献: Fu, L.,Wang, S.,Wang, X.,Wang, P.,Zheng, Y.,Yao, D.,Guo, M.,Zhang, L.,Ouyang, L.; Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.; Sci Rep, 6:3-3, 2016; PubMed: 28442756; DOI: 10.1038/s41598-016-0007-2

実験手法

X-RAY DIFFRACTION (4.01 Å)