5H9P

Crystal Structure of Human Galectin-3 CRD in Complex with TD139

Summary for 5H9P

• Entry DOI: 10.2210/pdb5h9p/pdb
• Related: 4XBN 5H9Q 5H9R 5H9S
• Descriptor: Galectin-3, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside (3 entities in total)
• Functional Keywords: galectin, thio-digalactoside (tdg), pi-arginine interaction, sugar binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P17931
• Total number of polymer chains: 1
• Total formula weight: 18521.05

Authors

Hsieh, T.J.,Lin, H.Y.,Lin, C.H. (deposition date: 2015-12-29, release date: 2016-06-29, Last modification date: 2023-11-08)

• Primary citation: Hsieh, T.J.,Lin, H.Y.,Tu, Z.,Lin, T.C.,Wu, S.C.,Tseng, Y.Y.,Liu, F.T.,Danny Hsu, S.T.,Lin, C.H.; Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors; Sci Rep, 6:29457-29457, 2016; PubMed: 27416897; DOI: 10.1038/srep29457

Experimental method

X-RAY DIFFRACTION (2.04 Å)