5H9P

Crystal Structure of Human Galectin-3 CRD in Complex with TD139

5H9P の概要

関連するPDBエントリー4XBN 5H9Q 5H9R 5H9S
分子名称Galectin-3, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside (3 entities in total)
機能のキーワードgalectin, thio-digalactoside (tdg), pi-arginine interaction, sugar binding protein
由来する生物種Homo sapiens (Human)
細胞内の位置Cytoplasm P17931
ポリマー鎖数1
分子量合計18521.05
構造登録者
Hsieh, T.J.,Lin, H.Y.,Lin, C.H. (登録日: 2015-12-29, 公開日: 2016-06-29, 最終更新日: 2016-07-27)
主引用文献
Hsieh, T.J.,Lin, H.Y.,Tu, Z.,Lin, T.C.,Wu, S.C.,Tseng, Y.Y.,Liu, F.T.,Danny Hsu, S.T.,Lin, C.H.
Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6:29457-29457, 2016
PubMed: 27416897 (主引用文献が同じPDBエントリー)
DOI: 10.1038/srep29457
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.04 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1952002.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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