5H8X

Crystal structure of the complex MMP-8/BF471 (catechol inhibitor)

Summary for 5H8X

• Entry DOI: 10.2210/pdb5h8x/pdb
• Descriptor: Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: catechol function, mmps, inhibitor, metalloprotese, zinc binding function, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasmic granule: P22894
• Total number of polymer chains: 1
• Total formula weight: 19200.72

Authors

Pochetti, G.,Montanari, R.,Capelli, D.,Tortorella, P. (deposition date: 2015-12-24, release date: 2016-11-02, Last modification date: 2024-01-10)

• Primary citation: Tauro, M.,Laghezza, A.,Loiodice, F.,Piemontese, L.,Caradonna, A.,Capelli, D.,Montanari, R.,Pochetti, G.,Di Pizio, A.,Agamennone, M.,Campestre, C.,Tortorella, P.; Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.; J Enzyme Inhib Med Chem, 31:25-37, 2016; PubMed: 27556138; DOI: 10.1080/14756366.2016.1217853

Experimental method

X-RAY DIFFRACTION (1.3 Å)