5H6Q

Crystal structure of LSD1-CoREST in complex with peptide 11

5H6Q の概要

• エントリーDOI: 10.2210/pdb5h6q/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, peptide SRTMQTARKSTGGKAPRKQLK, ... (6 entities in total)
• 機能のキーワード: demethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription-inhibitor complex, oxidoreductase/transcription/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : O60341 Q9UKL0
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 93675.66

構造登録者

Kikuchi, M.,Amano, Y.,Sato, S.,Yokoyama, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (登録日: 2016-11-14, 公開日: 2017-04-12, 最終更新日: 2023-11-08)

• 主引用文献: Amano, Y.,Kikuchi, M.,Sato, S.,Yokoyama, S.,Umehara, T.,Umezawa, N.,Higuchi, T.; Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.; Bioorg. Med. Chem., 25:2617-2624, 2017; PubMed: 28336409; DOI: 10.1016/j.bmc.2017.03.016

実験手法

X-RAY DIFFRACTION (2.53 Å)