5H1U

Complex structure of TRIM24 PHD-bromodomain and inhibitor 2

Summary for 5H1U

• Entry DOI: 10.2210/pdb5h1u/pdb
• Related: 5H1T 5H1V
• Descriptor: Transcription intermediary factor 1-alpha, 2-amino-1,3-benzothiazole-6-carboxamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: transcription transcription inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : O15164
• Total number of polymer chains: 4
• Total formula weight: 86455.84

Authors

Liu, J. (deposition date: 2016-10-11, release date: 2017-02-22, Last modification date: 2023-11-08)

• Primary citation: Liu, J.,Li, F.,Bao, H.,Jiang, Y.,Zhang, S.,Ma, R.,Gao, J.,Wu, J.,Ruan, K.; The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network; FEBS J., 284:1082-1095, 2017; PubMed: 28207202; DOI: 10.1111/febs.14041

Experimental method

X-RAY DIFFRACTION (1.901 Å)