5H15

EED in complex with PRC2 allosteric inhibitor EED709

Summary for 5H15

• Entry DOI: 10.2210/pdb5h15/pdb
• Related: 5H13 5H14 5H17 5H19 5H24 5H25
• Descriptor: Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, ... (4 entities in total)
• Functional Keywords: eed, prc2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: O75530 Q15910
• Total number of polymer chains: 4
• Total formula weight: 92683.81

Authors

Zhao, K.,Zhao, M.,Luo, X.,Zhang, H. (deposition date: 2016-10-08, release date: 2017-01-25, Last modification date: 2023-11-08)

• Primary citation: Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K.; Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED; PLoS ONE, 12:e0169855-e0169855, 2017; PubMed: 28072869; DOI: 10.1371/journal.pone.0169855

Experimental method

X-RAY DIFFRACTION (2.27 Å)