5H08

Human PTPRZ D1 domain complexed with NAZ2329

Summary for 5H08

• Entry DOI: 10.2210/pdb5h08/pdb
• Related: 5AWX
• Descriptor: Receptor-type tyrosine-protein phosphatase zeta, 3-{[2-Ethoxy-5-(trifluoromethyl)benzyl]sulfanyl}-N-(phenylsulfonyl)thiophene-2-carboxamide (3 entities in total)
• Functional Keywords: protein tyrosine phosphatase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted : P23471
• Total number of polymer chains: 1
• Total formula weight: 34455.96

Authors

Sugawara, H. (deposition date: 2016-10-04, release date: 2017-07-26, Last modification date: 2023-11-08)

• Primary citation: Fujikawa, A.,Sugawara, H.,Tanaka, T.,Matsumoto, M.,Kuboyama, K.,Suzuki, R.,Tanga, N.,Ogata, A.,Masumura, M.,Noda, M.; Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells; Sci Rep, 7:5609-5609, 2017; PubMed: 28717188; DOI: 10.1038/s41598-017-05931-8

Experimental method

X-RAY DIFFRACTION (2.53 Å)