5GRJ

Crystal structure of human PD-L1 with monoclonal antibody avelumab

Summary for 5GRJ

• Entry DOI: 10.2210/pdb5grj/pdb
• Descriptor: avelumab H chain, avelumab L chain, Programmed cell death 1 ligand 1 (3 entities in total)
• Functional Keywords: pd-l1, avelumab, monoclonal antibody, tumor immunothepapy, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
• Total number of polymer chains: 3
• Total formula weight: 49827.89

Authors

Liu, K.,Tan, S.,Chai, Y.,Chen, D.,Song, H.,Zhang, C.W.-H.,Shi, Y.,Liu, J.,Tan, W.,Lyu, J.,Gao, S.,Yan, J.,Qi, J.,Gao, G.F. (deposition date: 2016-08-11, release date: 2016-11-02, Last modification date: 2023-11-08)

• Primary citation: Liu, K.,Tan, S.,Chai, Y.,Chen, D.,Song, H.,Zhang, C.W.,Shi, Y.,Liu, J.,Tan, W.,Lyu, J.,Gao, S.,Yan, J.,Qi, J.,Gao, G.F.; Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.; Cell Res., 27:151-153, 2017; PubMed: 27573173; DOI: 10.1038/cr.2016.102

Experimental method

X-RAY DIFFRACTION (3.206 Å)