5GHP
Crystal structure of human MTH1(G2K/D120A mutant) in complex with 2-oxo-dATP
Summary for 5GHP
| Entry DOI | 10.2210/pdb5ghp/pdb |
| Related | 5GHI 5GHJ 5GHM 5GHN 5GHO 5GHQ |
| Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION (3 entities in total) |
| Functional Keywords | alpha-beta-alpha sandwich, hydrolase, dna damage, dna repair, dna replication |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 36045.14 |
| Authors | Nakamura, T.,Waz, S.,Hirata, K.,Nakabeppu, Y.,Yamagata, Y. (deposition date: 2016-06-20, release date: 2017-01-04, Last modification date: 2024-03-20) |
| Primary citation | Waz, S.,Nakamura, T.,Hirata, K.,Koga-Ogawa, Y.,Chirifu, M.,Arimori, T.,Tamada, T.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y. Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292:2785-2794, 2017 Cited by PubMed: 28035004DOI: 10.1074/jbc.M116.749713 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.192 Å) |
Structure validation
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