5GHM

Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 7.0

Summary for 5GHM

• Entry DOI: 10.2210/pdb5ghm/pdb
• Related: 5GHI 5GHJ 5GHN 5GHO 5GHP 5GHQ
• Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION, ... (4 entities in total)
• Functional Keywords: alpha-beta-alpha sandwich, hydrolase, dna damage, dna repair, dna replication
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37154.56

Authors

Nakamura, T.,Waz, S.,Hirata, K.,Nakabeppu, Y.,Yamagata, Y. (deposition date: 2016-06-20, release date: 2017-01-04, Last modification date: 2024-03-20)

• Primary citation: Waz, S.,Nakamura, T.,Hirata, K.,Koga-Ogawa, Y.,Chirifu, M.,Arimori, T.,Tamada, T.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y.; Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity; J. Biol. Chem., 292:2785-2794, 2017; PubMed: 28035004; DOI: 10.1074/jbc.M116.749713

Experimental method

X-RAY DIFFRACTION (1.5 Å)