5GDS

HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX

5GDS の概要

• エントリーDOI: 10.2210/pdb5gds/pdb
• 分子名称: ALPHA-THROMBIN, HIRUNORM V, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: serine protease-inhibitor complex, thrombin, thrombin synthetic inhibitors, antithrombotics, hirunorms, hirudin-like binding mode, blood coagulation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37056.17

構造登録者

De Simone, G.,Lombardi, A.,Galdiero, S.,Nastri, F.,Della Morte, R.,Staiano, N.,Pedone, C.,Bolognesi, M.,Pavone, V. (登録日: 1997-07-17, 公開日: 1998-01-21, 最終更新日: 2023-08-09)

• 主引用文献: De Simone, G.,Lombardi, A.,Galdiero, S.,Nastri, F.,Della Morte, R.,Staiano, N.,Pedone, C.,Bolognesi, M.,Pavone, V.; Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.; Protein Sci., 7:243-253, 1998; PubMed: 9521099

実験手法

X-RAY DIFFRACTION (2.1 Å)