5G5W

Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal Glucocorticoid receptor modulators

5G5W の概要

• エントリーDOI: 10.2210/pdb5g5w/pdb
• 分子名称: GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: hormone, glucocorticoid receptor, nuclear hormone receptor, steroid receptor, signaling protein, ligand complex, peptide complex
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34415.56

構造登録者

Hemmerling, M.,Edman, K.,Lepisto, M.,Eriksson, A.,Ivanova, S.,Dahmen, J.,Rehwinkel, H.,Berger, M.,Hendrickx, R.,Dearman, M.,Jellesmark-Jensen, T.,Wissler, L.,Hansson, T. (登録日: 2016-06-08, 公開日: 2017-02-15, 最終更新日: 2024-01-10)

• 主引用文献: Hemmerling, M.,Edman, K.,Lepisto, M.,Eriksson, A.,Ivanova, S.,Dahmen, J.,Rehwinkel, H.,Berger, M.,Hendrickx, R.,Dearman, M.,Jensen, T.J.,Wissler, L.,Hansson, T.; Discovery of Indazole Ethers as Novel, Potent, Non-Steroidal Glucocorticoid Receptor Modulators.; Bioorg.Med.Chem.Lett., 26:5741-, 2017; PubMed: 27810243; DOI: 10.1016/J.BMCL.2016.10.052

実験手法

X-RAY DIFFRACTION (2.2 Å)