5G5L

RNA polymerase I-Rrn3 complex at 4.8 A resolution

5G5L の概要

• エントリーDOI: 10.2210/pdb5g5l/pdb
• EMDBエントリー: 3439
• 分子名称: DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5, DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2, ... (16 entities in total)
• 機能のキーワード: rna polymerase, transciption
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKERS YEAST); 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 663194.65

構造登録者

Engel, C.,Plitzko, J.,Cramer, P. (登録日: 2016-05-26, 公開日: 2016-07-27, 最終更新日: 2024-10-09)

主引用文献

Engel, C.,Plitzko, J.,Cramer, P.
RNA Polymerase I-Rrn3 Complex at 4.8 A Resolution
Nat.Commun., 7:12129-, 2016

PubMed Abstract: Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 Å resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation.

PubMed: 27418309
DOI: 10.1038/NCOMMS12129

実験手法

ELECTRON MICROSCOPY (4.8 Å)