5G4N

Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083

Summary for 5G4N

• Entry DOI: 10.2210/pdb5g4n/pdb
• Related: 5G4M 5G4O
• Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION, 1-[9-(2,2-difluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, ... (5 entities in total)
• Functional Keywords: transcription, p53, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone, fluorine-protein interactions
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 49833.15

Authors

Joerger, A.C.,Bauer, M.,Jones, R.N.,Spencer, J. (deposition date: 2016-05-13, release date: 2016-06-22, Last modification date: 2024-01-10)

• Primary citation: Bauer, M.R.,Jones, R.N.,Baud, M.G.J.,Wilcken, R.,Boeckler, F.M.,Fersht, A.R.,Joerger, A.C.,Spencer, J.; Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs.; Acs Chem.Biol., 11:2265-, 2016; PubMed: 27267810; DOI: 10.1021/ACSCHEMBIO.6B00315

Experimental method

X-RAY DIFFRACTION (1.35 Å)