5G4M
Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083
Summary for 5G4M
Entry DOI | 10.2210/pdb5g4m/pdb |
Related | 5G4N 5G4O |
Descriptor | CELLULAR TUMOR ANTIGEN P53, ZINC ION, 1-[9-(2-fluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, ... (6 entities in total) |
Functional Keywords | transcription, p53, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone, fluorine-protein interactions |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 49859.24 |
Authors | Joerger, A.C.,Bauer, M. (deposition date: 2016-05-13, release date: 2016-06-22, Last modification date: 2024-01-10) |
Primary citation | Bauer, M.R.,Jones, R.N.,Baud, M.G.J.,Wilcken, R.,Boeckler, F.M.,Fersht, A.R.,Joerger, A.C.,Spencer, J. Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11:2265-, 2016 Cited by PubMed: 27267810DOI: 10.1021/ACSCHEMBIO.6B00315 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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