5G4M

Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083

5G4M の概要

• エントリーDOI: 10.2210/pdb5g4m/pdb
• 関連するPDBエントリー: 5G4N 5G4O
• 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION, 1-[9-(2-fluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, ... (6 entities in total)
• 機能のキーワード: transcription, p53, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone, fluorine-protein interactions
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49859.24

構造登録者

Joerger, A.C.,Bauer, M. (登録日: 2016-05-13, 公開日: 2016-06-22, 最終更新日: 2024-01-10)

• 主引用文献: Bauer, M.R.,Jones, R.N.,Baud, M.G.J.,Wilcken, R.,Boeckler, F.M.,Fersht, A.R.,Joerger, A.C.,Spencer, J.; Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs.; Acs Chem.Biol., 11:2265-, 2016; PubMed: 27267810; DOI: 10.1021/ACSCHEMBIO.6B00315

実験手法

X-RAY DIFFRACTION (1.38 Å)