5G22
Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 26)
Summary for 5G22
Entry DOI | 10.2210/pdb5g22/pdb |
Related | 5G1Z 5G20 5G21 |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, ETHYL 4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL), ... (7 entities in total) |
Functional Keywords | transferase, myristoylation, malaria, inhibitor, quinoline, drug design |
Biological source | PLASMODIUM VIVAX (MALARIA PARASITE P. VIVAX) |
Total number of polymer chains | 3 |
Total formula weight | 139862.50 |
Authors | Goncalves, V.,Brannigan, J.A.,Laporte, A.,Bell, A.S.,Roberts, S.M.,Wilkinson, A.J.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2016-04-06, release date: 2017-02-15, Last modification date: 2024-05-08) |
Primary citation | Goncalves, V.,Brannigan, J.A.,Laporte, A.,Bell, A.S.,Roberts, S.M.,Wilkinson, A.J.,Leatherbarrow, R.J.,Tate, E.W. Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm, 8:191-197, 2017 Cited by PubMed: 28626547DOI: 10.1039/c6md00531d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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