5G21
Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26).
Summary for 5G21
Entry DOI | 10.2210/pdb5g21/pdb |
Related | 5G1Z 5G20 5G22 |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, TETRADECANOYL-COA, ... (5 entities in total) |
Functional Keywords | transferase, myristoylation, malaria, inhibitor, drug design, quinoline |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 1 |
Total formula weight | 48989.90 |
Authors | Goncalves, V.,Brannigan, J.A.,Laporte, A.,Bell, A.S.,Roberts, S.M.,Wilkinson, A.J.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2016-04-06, release date: 2017-02-15, Last modification date: 2017-06-28) |
Primary citation | Goncalves, V.,Brannigan, J.A.,Laporte, A.,Bell, A.S.,Roberts, S.M.,Wilkinson, A.J.,Leatherbarrow, R.J.,Tate, E.W. Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm, 8:191-197, 2017 Cited by PubMed: 28626547DOI: 10.1039/c6md00531d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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