5FZX

High resolution solution NMR structure of the spider venom peptide U5- scytotoxin-Sth1a

5FZX の概要

• エントリーDOI: 10.2210/pdb5fzx/pdb
• 関連するPDBエントリー: 5FZV 5FZW
• NMR情報: BMRB: 26004
• 分子名称: U5-SCYTOTOXIN-STH1A (1 entity in total)
• 機能のキーワード: toxin, spider venom peptide, ick
• 由来する生物種: SCYTODES THORACICA (SPITTING SPIDER)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3924.34

構造登録者

Loening, N.M. (登録日: 2016-03-15, 公開日: 2016-06-08, 最終更新日: 2024-11-06)

主引用文献

Ariki, N.K.,Munoz, L.E.,Armitage, E.L.,Goodstein, F.R.,George, K.G.,Smith, V.L.,Vetter, I.,Herzig, V.,King, G.F.,Loening, N.M.
Characterization of Three Venom Peptides from the Spitting Spider Scytodes Thoracica.
Plos One, 11:56291-, 2016

PubMed Abstract: We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

PubMed: 27227898
DOI: 10.1371/JOURNAL.PONE.0156291

実験手法

SOLUTION NMR