5FYL

Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22

5FYL の概要

• エントリーDOI: 10.2210/pdb5fyl/pdb
• 関連するPDBエントリー: 5FYJ 5FYK
• 分子名称: BG505 GP120 ENV ECTODOMAIN, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (21 entities in total)
• 機能のキーワード: viral protein, hiv, envelope, glycan, trimer
• 由来する生物種: HUMAN IMMUNODEFICIENCY VIRUS 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 190568.73

構造登録者

Stewart-Jones, G.B.E.,Zhou, T.,Thomas, P.V.,Kwong, P.D. (登録日: 2016-03-08, 公開日: 2016-04-27, 最終更新日: 2024-01-10)

• 主引用文献: Stewart-Jones, G.B.E.,Soto, C.,Lemmin, T.,Chuang, G.Y.,Druz, A.,Kong, R.,Thomas, P.V.,Wagh, K.,Zhou, T.,Behrens, A.J.,Bylund, T.,Choi, C.W.,Davison, J.R.,Georgiev, I.S.,Joyce, M.G.,Kwon, Y.D.,Pancera, M.,Taft, J.,Yang, Y.,Zhang, B.,Shivatare, S.S.,Shivatare, V.S.,Lee, C.C.D.,Wu, C.Y.,Bewley, C.A.,Burton, D.R.,Koff, W.C.,Connors, M.,Crispin, M.,Korber, B.T.,Wong, C.H.,Mascola, J.R.,Kwong, P.D.; Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G; Cell(Cambridge,Mass.), 165:813-, 2016; PubMed: 27114034; DOI: 10.1016/J.CELL.2016.04.010

実験手法

X-RAY DIFFRACTION (3.1 Å)