5FPS

Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 3-aminobenzene-1,2-dicarboxylic acid (AT1246) in an alternate binding site.

5FPS の概要

• エントリーDOI: 10.2210/pdb5fps/pdb
• 関連するPDBエントリー: 5FP5 5FP6 5FPD 5FPE 5FPM 5FPN 5FPO 5FPR 5FPT 5FPY
• 分子名称: HEPATITIS C VIRUS FULL-LENGTH NS3 COMPLEX, 3-AMINOBENZENE-1,2-DICARBOXYLIC ACID (3 entities in total)
• 機能のキーワード: hepatitis c virus, hcv, ns3 complex, protease-helicase, hydrolase, protein-ligand complex, fragment screening, alternate binding site, at1246.
• 由来する生物種: HEPATITIS C VIRUS (ISOLATE BK)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 142101.07

構造登録者

Jhoti, H.,Ludlow, R.F.,Saini, H.K.,Tickle, I.J.,Verdonk, M.,Williams, P.A. (登録日: 2015-12-02, 公開日: 2015-12-23, 最終更新日: 2024-01-10)

• 主引用文献: Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H.; Detection of Secondary Binding Sites in Proteins Using Fragment Screening.; Proc.Natl.Acad.Sci.USA, 112:15910-, 2015; PubMed: 26655740; DOI: 10.1073/PNAS.1518946112

実験手法

X-RAY DIFFRACTION (2.68 Å)