5FPM

Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site.

5FPM の概要

• エントリーDOI: 10.2210/pdb5fpm/pdb
• 関連するPDBエントリー: 5FP5 5FP6 5FPD 5FPE 5FPN 5FPO 5FPR 5FPS 5FPT 5FPY
• 分子名称: HEAT SHOCK-RELATED 70KDA PROTEIN 2, 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL (3 entities in total)
• 機能のキーワード: heat shock-related protein, heat shock, chaperone, hsp70, hspa2, protein-ligand complex, fragment screening, alternate binding site, at809.
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85122.42

構造登録者

Jhoti, H.,Ludlow, R.F.,Patel, S.,Saini, H.K.,Tickle, I.J.,Verdonk, M. (登録日: 2015-12-02, 公開日: 2015-12-16, 最終更新日: 2024-01-10)

• 主引用文献: Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H.; Detection of Secondary Binding Sites in Proteins Using Fragment Screening.; Proc.Natl.Acad.Sci.USA, 112:15910-, 2015; PubMed: 26655740; DOI: 10.1073/PNAS.1518946112

実験手法

X-RAY DIFFRACTION (1.96 Å)