5FO9

Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17)

Summary for 5FO9

Related5FO7 5FO8 5FOA 5FOB
DescriptorCOMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1, ... (4 entities in total)
Functional Keywordslipid binding protein, complement system, immune system, plasma protein, regulators of complement activity, cofactor activity, decay accelerating activity
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01024 P17927
Membrane; Single-pass type I membrane protein P01024
Total number of polymer chains6
Total molecular weight394612.41
Authors
Forneris, F.,Wu, J.,Xue, X.,Gros, P. (deposition date: 2015-11-18, release date: 2016-04-06, Last modification date: 2016-06-01)
Primary citation
Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P.
Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35:1133-, 2016
PubMed: 27013439 (PDB entries with the same primary citation)
DOI: 10.15252/EMBJ.201593673
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29170.1%0.9%9.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution