5FO3

ZapC cell division regulator from E. coli

5FO3 の概要

• エントリーDOI: 10.2210/pdb5fo3/pdb
• 分子名称: CELL DIVISION PROTEIN ZAPC (1 entity in total)
• 機能のキーワード: cell cycle, ftsz, bacterial cell division, z-ring associated protein c
• 由来する生物種: ESCHERICHIA COLI
• 細胞内の位置: Cytoplasm : P75862
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42161.43

構造登録者

Ortiz, C.,Kureisaite-Ciziene, D.,Schmitz, F.,Vicente, M.,Lowe, J. (登録日: 2015-11-18, 公開日: 2015-11-25, 最終更新日: 2024-11-06)

主引用文献

Ortiz, C.,Kureisaite-Ciziene, D.,Schmitz, F.,Mclaughlin, S.H.,Vicente, M.,Lowe, J.
Crystal Structure of the Z-Ring Associated Cell Division Protein Zapc from Escherichia Coli.
FEBS Lett., 589:3822-, 2015

PubMed Abstract: Bacterial cell division involves a contractile ring that organises downstream proteins at the division site and which contains the tubulin homologue FtsZ. ZapC has been discovered as a non-essential regulator of FtsZ. It localises to the septal ring and deletion of zapC leads to a mild phenotype, while overexpression inhibits cell division. Interference with cell division is facilitated by an interaction with FtsZ. Here, we present the 2.9 Å crystal structure of ZapC from Escherichia coli. ZapC forms a dimer and comprises two domains that belong to the Royal superfamily of which many members bind methylated arginines or lysines. ZapC contains an N-terminal chromo-like domain and a Tudor-like C-terminal domain. We show by ITC that ZapC binds the C-terminal tail of FtsZ.

PubMed: 26619764
DOI: 10.1016/J.FEBSLET.2015.11.030

実験手法

X-RAY DIFFRACTION (2.9 Å)