5FI4
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model
Summary for 5FI4
Entry DOI | 10.2210/pdb5fi4/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, GLYCEROL, ... (5 entities in total) |
Functional Keywords | lipid kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 164503.73 |
Authors | Elling, R.A.,Knapp, M.S.,Han, W.,Daniel, L.M.,Xy, Y.,Burger, M.T.,Ni, Z.,Smith, A.,Lan, J.,Williams, T.,Verhagen, J.,Huh, K.,Merritt, H.,Chan, J.,Kaufman, S.,Voliva, C.F.,Pecchi, S. (deposition date: 2015-12-22, release date: 2016-02-03, Last modification date: 2024-03-06) |
Primary citation | Han, W.,Menezes, D.L.,Xu, Y.,Knapp, M.S.,Elling, R.,Burger, M.T.,Ni, Z.J.,Smith, A.,Lan, J.,Williams, T.E.,Verhagen, J.,Huh, K.,Merritt, H.,Chan, J.,Kaufman, S.,Voliva, C.F.,Pecchi, S. Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Bioorg.Med.Chem.Lett., 26:742-746, 2016 Cited by PubMed: 26774655DOI: 10.1016/j.bmcl.2016.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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