5FI4

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model

5FI4 の概要

• エントリーDOI: 10.2210/pdb5fi4/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: lipid kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 164503.73

構造登録者

Elling, R.A.,Knapp, M.S.,Han, W.,Daniel, L.M.,Xy, Y.,Burger, M.T.,Ni, Z.,Smith, A.,Lan, J.,Williams, T.,Verhagen, J.,Huh, K.,Merritt, H.,Chan, J.,Kaufman, S.,Voliva, C.F.,Pecchi, S. (登録日: 2015-12-22, 公開日: 2016-02-03, 最終更新日: 2024-03-06)

• 主引用文献: Han, W.,Menezes, D.L.,Xu, Y.,Knapp, M.S.,Elling, R.,Burger, M.T.,Ni, Z.J.,Smith, A.,Lan, J.,Williams, T.E.,Verhagen, J.,Huh, K.,Merritt, H.,Chan, J.,Kaufman, S.,Voliva, C.F.,Pecchi, S.; Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.; Bioorg.Med.Chem.Lett., 26:742-746, 2016; PubMed: 26774655; DOI: 10.1016/j.bmcl.2016.01.003

実験手法

X-RAY DIFFRACTION (2.5 Å)