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5FE9

Crystal structure of human PCAF bromodomain in complex with compound SL1122 (compound 13)

Summary for 5FE9
Entry DOI10.2210/pdb5fe9/pdb
DescriptorHistone acetyltransferase KAT2B, ~{N}-(1,4-dimethyl-2-oxidanylidene-quinolin-7-yl)methanesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordssignaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc)
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : Q92831
Total number of polymer chains2
Total formula weight28939.44
Authors
Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-12-16, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citationChaikuad, A.,Lang, S.,Brennan, P.E.,Temperini, C.,Fedorov, O.,Hollander, J.,Nachane, R.,Abell, C.,Muller, S.,Siegal, G.,Knapp, S.
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
J.Med.Chem., 59:1648-1653, 2016
Cited by
PubMed: 26731131
DOI: 10.1021/acs.jmedchem.5b01719
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

217705

數據於2024-03-27公開中

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