5FE9

Crystal structure of human PCAF bromodomain in complex with compound SL1122 (compound 13)

5FE9 の概要

• エントリーDOI: 10.2210/pdb5fe9/pdb
• 分子名称: Histone acetyltransferase KAT2B, ~{N}-(1,4-dimethyl-2-oxidanylidene-quinolin-7-yl)methanesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: signaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc)
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q92831
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28939.44

構造登録者

Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2015-12-16, 公開日: 2016-01-13, 最終更新日: 2024-01-10)

• 主引用文献: Chaikuad, A.,Lang, S.,Brennan, P.E.,Temperini, C.,Fedorov, O.,Hollander, J.,Nachane, R.,Abell, C.,Muller, S.,Siegal, G.,Knapp, S.; Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.; J.Med.Chem., 59:1648-1653, 2016; PubMed: 26731131; DOI: 10.1021/acs.jmedchem.5b01719

実験手法

X-RAY DIFFRACTION (2.35 Å)