5FCK

COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 5

Summary for 5FCK

Entry DOI	10.2210/pdb5fck/pdb
Descriptor	Complement factor D, 1-[2-[(1~{R},3~{S},5~{R})-3-[[(1~{R})-1-(3-chloranyl-2-fluoranyl-phenyl)ethyl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]pyrazolo[3,4-c]pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P00746
Total number of polymer chains	1
Total formula weight	25320.09
Authors	Mac Sweeney, A. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2024-01-10)
Primary citation	Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K. Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat.Chem.Biol., 12:1105-1110, 2016 Cited by PubMed: 27775713 DOI: 10.1038/nchembio.2208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation