5FBI

COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 3b

Summary for 5FBI

Entry DOI	10.2210/pdb5fbi/pdb
Descriptor	Complement factor D, GLYCEROL, 3-[(2-aminocarbonyl-1~{H}-indol-5-yl)oxymethyl]benzoic acid, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P00746
Total number of polymer chains	1
Total formula weight	25141.52
Authors	Ostermann, N.,Zink, F. (deposition date: 2015-12-14, release date: 2016-10-26, Last modification date: 2024-01-10)
Primary citation	Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K. Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat.Chem.Biol., 12:1105-1110, 2016 Cited by PubMed: 27775713 DOI: 10.1038/nchembio.2208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation