5FB8

Structure of Interleukin-16 bound to the 14.1 antibody

Summary for 5FB8

• Entry DOI: 10.2210/pdb5fb8/pdb
• Related: 1I16
• Descriptor: Anti-IL-16 antibody 14.1 Fab domain Kappa Chain, Anti-IL-16 antibody 14.1 Fab domain Heavy Chain, Pro-interleukin-16, ... (7 entities in total)
• Functional Keywords: cytokine, interleukin, antibody, complex, immune system
• Biological source: Mus musculus (House Mouse); More
• Cellular location: Interleukin-16: Secreted. Isoform 1: Cytoplasm . Isoform 3: Cytoplasm: Q14005
• Total number of polymer chains: 3
• Total formula weight: 59630.57

Authors

Hall, G.,Cowan, R.,Bayliss, R.,Carr, M. (deposition date: 2015-12-14, release date: 2016-06-08, Last modification date: 2024-01-10)

• Primary citation: Hall, G.,Cullen, E.,Sawmynaden, K.,Arnold, J.,Fox, S.,Cowan, R.,Muskett, F.W.,Matthews, D.,Merritt, A.,Kettleborough, C.,Cruikshank, W.,Taylor, D.,Bayliss, R.,Carr, M.D.; Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.; J.Biol.Chem., 291:16840-16848, 2016; PubMed: 27231345; DOI: 10.1074/jbc.M115.709303

Experimental method

X-RAY DIFFRACTION (2.07 Å)