5F9K

Dictyostelium discoideum dUTPase at 2.2 Angstrom

5F9K の概要

• エントリーDOI: 10.2210/pdb5f9k/pdb
• 分子名称: Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Dictyostelium discoideum (Slime mold)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48243.76

構造登録者

Inoguchi, N.,Chia, C.P.,Heck, K.,Moriyama, H. (登録日: 2015-12-09, 公開日: 2016-12-14, 最終更新日: 2023-09-27)

主引用文献

Chia, C.P.,Inoguchi, N.,Varon, K.C.,Bartholomai, B.M.,Moriyama, H.
Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus.
Bmc Res Notes, 13:16-16, 2020

PubMed Abstract: The nuclear and mitochondrial genomes of Dictyostelium discoideum, a unicellular eukaryote, have relatively high A+T-contents of 77.5% and 72.65%, respectively. To begin to investigate how the pyrimidine biosynthetic pathway fulfills the demand for dTTP, we determined the catalytic properties and structure of the key enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) that hydrolyzes dUTP to dUMP, the precursor of dTTP.

PubMed: 31910901
DOI: 10.1186/s13104-019-4879-7

実験手法

X-RAY DIFFRACTION (2.179 Å)