5F63
Crystal structure of the first bromodomain of human BRD4 in complex with SG3-179
5F63 の概要
エントリーDOI | 10.2210/pdb5f63/pdb |
関連するPDBエントリー | 5F5Z 5F60 5F61 5F62 |
分子名称 | Bromodomain-containing protein 4, 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
機能のキーワード | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus: O60885 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15827.65 |
構造登録者 | |
主引用文献 | Ember, S.W.,Lambert, Q.T.,Berndt, N.,Gunawan, S.,Ayaz, M.,Tauro, M.,Zhu, J.Y.,Cranfill, P.J.,Greninger, P.,Lynch, C.C.,Benes, C.H.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E. Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics. Mol. Cancer Ther., 16:1054-1067, 2017 Cited by PubMed: 28336808DOI: 10.1158/1535-7163.MCT-16-0568-T 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.45 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード