5F62
Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2
Summary for 5F62
Entry DOI | 10.2210/pdb5f62/pdb |
Related | 5F5Z 5F60 5F61 5F63 |
Descriptor | Bromodomain-containing protein 4, ~{N}-[2-chloranyl-5-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-pyrimidin-4-yl]amino]phenyl]-2-methyl-propane-2-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 16033.89 |
Authors | Ember, S.W.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2015-12-04, release date: 2017-02-08, Last modification date: 2023-09-27) |
Primary citation | Ember, S.W.,Lambert, Q.T.,Berndt, N.,Gunawan, S.,Ayaz, M.,Tauro, M.,Zhu, J.Y.,Cranfill, P.J.,Greninger, P.,Lynch, C.C.,Benes, C.H.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E. Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics. Mol. Cancer Ther., 16:1054-1067, 2017 Cited by PubMed: 28336808DOI: 10.1158/1535-7163.MCT-16-0568-T PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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