5F62

Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-2

5F62 の概要

• エントリーDOI: 10.2210/pdb5f62/pdb
• 関連するPDBエントリー: 5F5Z 5F60 5F61 5F63
• 分子名称: Bromodomain-containing protein 4, ~{N}-[2-chloranyl-5-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-pyrimidin-4-yl]amino]phenyl]-2-methyl-propane-2-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16033.89

構造登録者

Ember, S.W.,Zhu, J.-Y.,Schonbrunn, E. (登録日: 2015-12-04, 公開日: 2017-02-08, 最終更新日: 2023-09-27)

• 主引用文献: Ember, S.W.,Lambert, Q.T.,Berndt, N.,Gunawan, S.,Ayaz, M.,Tauro, M.,Zhu, J.Y.,Cranfill, P.J.,Greninger, P.,Lynch, C.C.,Benes, C.H.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E.; Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.; Mol. Cancer Ther., 16:1054-1067, 2017; PubMed: 28336808; DOI: 10.1158/1535-7163.MCT-16-0568-T

実験手法

X-RAY DIFFRACTION (1.35 Å)