5F60
Crystal structure of the first bromodomain of human BRD4 in complex with SG3-014
5F60 の概要
エントリーDOI | 10.2210/pdb5f60/pdb |
関連するPDBエントリー | 5F5Z 5F61 5F62 5F63 |
分子名称 | Bromodomain-containing protein 4, ~{N}-[2-chloranyl-5-[[5-methyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]amino]phenyl]-2-methyl-propane-2-sulfonamide, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
機能のキーワード | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus: O60885 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15935.82 |
構造登録者 | |
主引用文献 | Ember, S.W.,Lambert, Q.T.,Berndt, N.,Gunawan, S.,Ayaz, M.,Tauro, M.,Zhu, J.Y.,Cranfill, P.J.,Greninger, P.,Lynch, C.C.,Benes, C.H.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E. Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics. Mol. Cancer Ther., 16:1054-1067, 2017 Cited by PubMed: 28336808DOI: 10.1158/1535-7163.MCT-16-0568-T 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.35 Å) |
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