5F4O

Protruding domain of GII.17 norovirus Kawasaki308

Summary for 5F4O

• Entry DOI: 10.2210/pdb5f4o/pdb
• Related: 5F4J 5F4M
• Descriptor: Capsid protein VP1, 1,2-ETHANEDIOL, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: norovirus, capsid protein, protruding domain, viral protein
• Biological source: Norovirus Hu/GII/JP/2015/GII.P17_GII.17/Kawasaki308
• Total number of polymer chains: 2
• Total formula weight: 69123.53

Authors

Singh, B.K.,Hansman, G.S. (deposition date: 2015-12-03, release date: 2016-01-13, Last modification date: 2024-01-10)

Primary citation

Singh, B.K.,Koromyslova, A.,Hefele, L.,Gurth, C.,Hansman, G.S.
Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.
J.Virol., 90:2710-2715, 2015

PubMed Abstract: Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.

PubMed: 26699640
DOI: 10.1128/JVI.03119-15

Experimental method

X-RAY DIFFRACTION (1.59 Å)