5F3I
Crystal structure of human KDM4A in complex with compound 54j
5F3I の概要
エントリーDOI | 10.2210/pdb5f3i/pdb |
分子名称 | Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-[3,5-bis(chloranyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ... (7 entities in total) |
機能のキーワード | epigenetics, demethylase, inhibitor, oxidoreductase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus : O75164 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 170259.28 |
構造登録者 | Le Bihan, Y.-V.,Dempster, S.,Westwood, I.M.,van Montfort, R.L.M. (登録日: 2015-12-02, 公開日: 2016-01-20, 最終更新日: 2024-01-10) |
主引用文献 | Bavetsias, V.,Lanigan, R.M.,Ruda, G.F.,Atrash, B.,McLaughlin, M.G.,Tumber, A.,Mok, N.Y.,Le Bihan, Y.V.,Dempster, S.,Boxall, K.J.,Jeganathan, F.,Hatch, S.B.,Savitsky, P.,Velupillai, S.,Krojer, T.,England, K.S.,Sejberg, J.,Thai, C.,Donovan, A.,Pal, A.,Scozzafava, G.,Bennett, J.M.,Kawamura, A.,Johansson, C.,Szykowska, A.,Gileadi, C.,Burgess-Brown, N.A.,von Delft, F.,Oppermann, U.,Walters, Z.,Shipley, J.,Raynaud, F.I.,Westaway, S.M.,Prinjha, R.K.,Fedorov, O.,Burke, R.,Schofield, C.J.,Westwood, I.M.,Bountra, C.,Muller, S.,van Montfort, R.L.,Brennan, P.E.,Blagg, J. 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59:1388-1409, 2016 Cited by PubMed: 26741168DOI: 10.1021/acs.jmedchem.5b01635 主引用文献が同じPDBエントリー |
実験手法 |
構造検証レポート
検証レポート(詳細版)をダウンロード