5F3F
Crystal structure of para-biphenyl-2-methyl-3'-methyl amide mannoside bound to FimH lectin domain
Summary for 5F3F
Entry DOI | 10.2210/pdb5f3f/pdb |
Related | 5F2F |
Descriptor | Protein FimH, 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide (3 entities in total) |
Functional Keywords | mannoside, fimh, adhesin, carbohydrate binding protein, sugar binding protein |
Biological source | Escherichia coli J96 |
Cellular location | Fimbrium: P08191 |
Total number of polymer chains | 1 |
Total formula weight | 17320.25 |
Authors | Klein, R.D.,Hultgren, S.J. (deposition date: 2015-12-02, release date: 2016-12-07, Last modification date: 2024-01-03) |
Primary citation | Mydock-McGrane, L.,Cusumano, Z.,Han, Z.,Binkley, J.,Kostakioti, M.,Hannan, T.,Pinkner, J.S.,Klein, R.,Kalas, V.,Crowley, J.,Rath, N.P.,Hultgren, S.J.,Janetka, J.W. Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections. J.Med.Chem., 59:9390-9408, 2016 Cited by PubMed: 27689912DOI: 10.1021/acs.jmedchem.6b00948 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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