5F2P

Crystal structure of the BRD9 bromodomain in complex with compound 3.

Summary for 5F2P

• Entry DOI: 10.2210/pdb5f2p/pdb
• Descriptor: BRD9, 2-(dimethylamino)-6-methyl-pyrido[4,3-d]pyrimidin-5-one (3 entities in total)
• Functional Keywords: bromodomain, inhibitor, regulatory proteins, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28907.98

Authors

Nar, H.,Fiegen, D.,Zoephel, A.,Bader, G. (deposition date: 2015-12-02, release date: 2016-03-09, Last modification date: 2024-01-10)

• Primary citation: Martin, L.J.,Koegl, M.,Bader, G.,Cockcroft, X.L.,Fedorov, O.,Fiegen, D.,Gerstberger, T.,Hofmann, M.H.,Hohmann, A.F.,Kessler, D.,Knapp, S.,Knesl, P.,Kornigg, S.,Muller, S.,Nar, H.,Rogers, C.,Rumpel, K.,Schaaf, O.,Steurer, S.,Tallant, C.,Vakoc, C.R.,Zeeb, M.,Zoephel, A.,Pearson, M.,Boehmelt, G.,McConnell, D.; Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.; J.Med.Chem., 59:4462-4475, 2016; PubMed: 26914985; DOI: 10.1021/acs.jmedchem.5b01865

Experimental method

X-RAY DIFFRACTION (1.8 Å)