5F2F
Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to FimH lectin domain
Summary for 5F2F
Entry DOI | 10.2210/pdb5f2f/pdb |
Descriptor | Protein FimH, 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | lectin, mannoside, immunoglobulin fold, carbohydrate binding protein, sugar binding protein |
Biological source | Escherichia coli J96 |
Total number of polymer chains | 1 |
Total formula weight | 17561.49 |
Authors | Kalas, V.,Hultgren, S.J. (deposition date: 2015-12-01, release date: 2016-05-04, Last modification date: 2023-09-27) |
Primary citation | Jarvis, C.,Han, Z.,Kalas, V.,Klein, R.,Pinkner, J.S.,Ford, B.,Binkley, J.,Cusumano, C.K.,Cusumano, Z.,Mydock-McGrane, L.,Hultgren, S.J.,Janetka, J.W. Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. Chemmedchem, 11:367-373, 2016 Cited by PubMed: 26812660DOI: 10.1002/cmdc.201600006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.665 Å) |
Structure validation
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