5F2F

Crystal structure of para-biphenyl-2-methyl-3', 5' di-methyl amide mannoside bound to FimH lectin domain

5F2F の概要

• エントリーDOI: 10.2210/pdb5f2f/pdb
• 分子名称: Protein FimH, 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: lectin, mannoside, immunoglobulin fold, carbohydrate binding protein, sugar binding protein
• 由来する生物種: Escherichia coli J96
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17561.49

構造登録者

Kalas, V.,Hultgren, S.J. (登録日: 2015-12-01, 公開日: 2016-05-04, 最終更新日: 2023-09-27)

• 主引用文献: Jarvis, C.,Han, Z.,Kalas, V.,Klein, R.,Pinkner, J.S.,Ford, B.,Binkley, J.,Cusumano, C.K.,Cusumano, Z.,Mydock-McGrane, L.,Hultgren, S.J.,Janetka, J.W.; Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.; Chemmedchem, 11:367-373, 2016; PubMed: 26812660; DOI: 10.1002/cmdc.201600006

実験手法

X-RAY DIFFRACTION (1.665 Å)