5F1Z
Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one
Summary for 5F1Z
Entry DOI | 10.2210/pdb5f1z/pdb |
Related | 5F20 |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one (3 entities in total) |
Functional Keywords | kinase, complex, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35203.30 |
Authors | Skene, R.J. (deposition date: 2015-12-01, release date: 2016-01-13, Last modification date: 2024-03-06) |
Primary citation | Yogo, T.,Nagamiya, H.,Seto, M.,Sasaki, S.,Shih-Chung, H.,Ohba, Y.,Tokunaga, N.,Lee, G.N.,Rhim, C.Y.,Yoon, C.H.,Cho, S.Y.,Skene, R.,Yamamoto, S.,Satou, Y.,Kuno, M.,Miyazaki, T.,Nakagawa, H.,Okabe, A.,Marui, S.,Aso, K.,Yoshida, M. Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. J.Med.Chem., 59:733-749, 2016 Cited by PubMed: 26701356DOI: 10.1021/acs.jmedchem.5b01857 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report