5F0H

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 28 at 1.99A resolution

5F0H の概要

• エントリーDOI: 10.2210/pdb5f0h/pdb
• 分子名称: HTH-type transcriptional regulator EthR, 3-[1-(4-cyanophenyl)piperidin-4-yl]-~{N}-[(4-piperidin-1-ylphenyl)methyl]propanamide (3 entities in total)
• 機能のキーワード: ethr, transcription, repressor, mycobacterium tuberculosis
• 由来する生物種: Mycobacterium tuberculosis CDC1551
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25689.84

構造登録者

Surade, S.,Blaszczyk, M.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (登録日: 2015-11-27, 公開日: 2016-02-03, 最終更新日: 2024-01-10)

• 主引用文献: Nikiforov, P.O.,Surade, S.,Blaszczyk, M.,Delorme, V.,Brodin, P.,Baulard, A.R.,Blundell, T.L.,Abell, C.; A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.; Org.Biomol.Chem., 14:2318-2326, 2016; PubMed: 26806381; DOI: 10.1039/c5ob02630j

実験手法

X-RAY DIFFRACTION (1.99 Å)