5F08

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium tuberculosis in complex with compound 14 at 1.92A resolution

5F08 の概要

• エントリーDOI: 10.2210/pdb5f08/pdb
• 分子名称: HTH-type transcriptional regulator EthR, ~{tert}-butyl ~{N}-methyl-~{N}-[[4-[4-(3-oxidanylidene-3-pyrrolidin-1-yl-propyl)piperidin-1-yl]phenyl]methyl]carbamate (3 entities in total)
• 機能のキーワード: ethr, transcription, repressor, mycobacterium tuberculosis
• 由来する生物種: Mycobacterium tuberculosis CDC1551
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25688.85

構造登録者

Surade, S.,Blaszczyk, M.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (登録日: 2015-11-27, 公開日: 2016-02-03, 最終更新日: 2024-01-10)

• 主引用文献: Nikiforov, P.O.,Surade, S.,Blaszczyk, M.,Delorme, V.,Brodin, P.,Baulard, A.R.,Blundell, T.L.,Abell, C.; A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.; Org.Biomol.Chem., 14:2318-2326, 2016; PubMed: 26806381; DOI: 10.1039/c5ob02630j

実験手法

X-RAY DIFFRACTION (1.92 Å)